Cross-platform multi-laboratory screening identifies HUWE1, USP33 and USP20 as negative-regulators of autophagy or mitophagy with relevance to neurodegeneration
Maria Luisa Giudici, Emily Coode, Wing Hei Au, Clément Rey, Maria Manifava, Ovidiu-Gabriel Capatina, Gregory G. Aldred, Stefan Milde, Verena Zyka, Wei‐Li Kuan, James Duce, Jonathan H. Clarke, Alexander J. Whitworth, Nicholas T. Ktistakis, John Skidmore
The paper identifies HUWE1, USP33, and USP20 as negative regulators of autophagy/mitophagy through cross-platform screening and validates their roles in neurodegeneration using multiple models.
bioRxiv · Sep 14, 2026 · PreprintNeuroscience