Simon Braun

The paper shows that intron retention and alternative exon choice are coupled through multistep exon recognition by the spliceosome, which is disrupted in cancer.

The paper investigates how RNA G-quadruplexes enable cooperative binding of HNRNPH and regulate splicing, showing clinical relevance in breast cancer.

The paper analyzes high-throughput mutagenesis data to show that exon definition is crucial for reliable alternative splicing in the RON proto-oncogene.