Recurrent chromosomal translocations in sarcomas create a mega-complex that mislocalizes NuA4/TIP60 to Polycomb target loci
Deepthi Sudarshan, Nikita Avvakumov, Marie‐Eve Lalonde, Nader Alerasool, Charles Joly-Beauparlant, Karine Jacquet, Amel Mameri, Jean‐Philippe Lambert, Justine Rousseau, Catherine Lachance, Éric R. Paquet, Lara Herrmann, Samarth Thonta Setty, Jérémy Loehr, Marcus Q. Bernardini, , Jacques Côté
This study identifies recurrent chromosomal translocations in sarcomas that merge NuA4/TIP60 and PRC2 complexes, leading to mislocalization of chromatin marks and aberrant gene expression.
bioRxiv · Mar 26, 2021Molecular Biology