Wei‐Kai Huang

This study investigates GABAergic neuron dysfunction in psychiatric disorder models, finding mutation-dependent synaptic deficits and shared gene expression changes in DISC1 mutant neurons.

This study shows SARS-CoV-2 can infect brain cells and organoids derived from human induced pluripotent stem cells, leading to cell death and inflammation, and suggests using these models to study the virus's effects on the brain.

The paper develops an improved Hi-C protocol and bias-correction pipeline to map chromatin loops in human neurogenesis and brain tissues, showing their role in neural differentiation and GWAS gene identification.