Catherine Z. Chen

A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike

This paper develops potent humanized nanobodies against SARS-CoV-2 spike protein, showing effectiveness against the Alpha variant and providing structural insights into their neutralization mechanism.

A Graph Convolutional Network-based screening strategy for rapid identification of SARS-CoV-2 cell-entry inhibitors

The paper develops a graph convolutional network to screen compounds for SARS-CoV-2 entry inhibitors, identifying 16 active compounds from 170,000 virtual candidates.

Discovery of TMPRSS2 inhibitors from virtual screening

This study identifies novel TMPRSS2 inhibitors through virtual screening and experimental validation, offering potential drug candidates for COVID-19 treatment.

Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism

This study shows SARS-CoV-2 can infect brain cells and organoids derived from human induced pluripotent stem cells, leading to cell death and inflammation, and suggests using these models to study the virus's effects on the brain.