Kamilla Sedov

This study uses optical genome mapping to compare structural variant profiles of iPSCs derived from different somatic cell sources, finding differences in SV burden and types between PBMC- and fibroblast-derived clones.

This study identifies APOE4/4-driven dysfunctional microglial states in Alzheimer's disease through multiomic analysis, revealing shifts toward terminal states with metabolic disruption and inflammatory signaling.

The paper identifies strategies to prevent transgene silencing during human pluripotent stem cell differentiation and introduces a robust vector construct.

The paper uses optical genome mapping to identify new smaller structural variants in the KOLF2.1J iPSC line, affecting genes relevant to neurodevelopment.