RNA triggers chronic stress during neuronal aging
Kevin Rhine, Elle Epstein, Natasha M. Carlson, Xuezhen Ge, Orel Mizrahi, Anika Kamat, Anita Hermann, William R. Brothers, John Ravits, Eric J. Bennett, Gülçin Pekkurnaz, Gene Wei-Ming Yeo
This study identifies mitochondrial-derived double-stranded RNA as a source of RNA stress in aged neurons, which activates the ISR through PKR and contributes to neurodegeneration.
bioRxiv · Aug 4, 2025 · PreprintCell Biology