Mark Louie D. Lopez

The paper shows that chromatin remodelling by NuRD enables enhancer resetting in response to ERK signalling in mouse ES cells, facilitating a rapid and precise transcriptional response.

This study identifies CHD4's role in restricting transcription factor binding to maintain regulatory function and silence cryptic enhancers.

The paper quantifies progressive changes in chromosome shape during cell divisions and finds that an alternative loop capture model explains the observed arm length to width relationship better than the loop extrusion model.