Nicola Reynolds

The paper shows that chromatin remodelling by NuRD enables enhancer resetting in response to ERK signalling in mouse ES cells, facilitating a rapid and precise transcriptional response.

This study identifies CHD4's role in restricting transcription factor binding to maintain regulatory function and silence cryptic enhancers.

The paper studies 3D genome structure changes in single mouse ES cells exiting pluripotency, finding reorganization of enhancer-promoter interactions through multiway chromatin hubs.

This study shows NuRD complex coordinates gene expression during lineage commitment by reducing transcriptional noise, priming genes for activation, and maintaining stable states.

This study compares NuRD's role in human and mouse pluripotent stem cells, finding that NuRD is required for transcriptional responses to differentiation signals in both, but with distinct functional differences between species.

The paper shows that MTA proteins in ES cell NuRD complex are functionally redundant, and NuRD is essential for maintaining differentiation trajectory during early lineage commitment.

This study shows the NuRD complex regulates enhancer chromatin structure and Mediator access to control transcription during lineage commitment in ES cells.