Christine A Bowen

This study identifies synaptic proteome changes in response to neuroinflammation, revealing mitochondrial and MAPK signaling disruptions in excitatory neurons linked to Alzheimer's disease.

This study shows that Kv1.3 inhibitors reduce neuropathology in a mouse AD model by modulating neuroinflammation, resilience, and neurovascular pathways through distinct cellular mechanisms.

The paper identifies RNA-binding proteins interacting with tau's repeat domain using proximity labeling, showing their enrichment in Alzheimer's and tauopathies.

The paper identifies novel Kv1.3 channel-interacting proteins in T-cells using proximity labeling, revealing interactions with immune signaling and trafficking machinery, and links some interactors to autoimmunity risk.

The paper identifies Kv1.3 potassium channel interactors in microglia using proximity labeling proteomics, revealing domain-specific interactions with immune signaling proteins during inflammation.

The paper uses TurboID-NES to profile proteomes of microglial and neuronal cell lines, showing it captures a significant portion of the proteome and responds to LPS treatment.