Ruiqi Li

The paper shows how coordinated Wnt and Hedgehog signaling creates sharp cell-type boundaries by synchronizing cell-cycle exit and differentiation.

This study shows that reducing cysteine, not methionine, improves immunometabolic fitness and extends healthy lifespan in aging organisms.

DiCoLo detects localized differential gene co-expression without clustering or cross-condition alignment, revealing coordinated gene programs in mouse hair follicle development.

LMD identifies localized genes in single-cell RNA-seq data to characterize cellular diversity without batch correction, outperforming existing methods.

The paper shows that coordinated timing between Wnt and Hedgehog signaling generates sharp cell-type boundaries during hair follicle development.

This study uses single-nucleus multiome sequencing to identify HIV-associated transcriptional and epigenetic changes in brain regions of individuals with HIV, revealing altered glial cell states and pro-inflammatory signaling.

BiPCA improves PCA for omics count data by adaptively rescaling noise, enhancing biological interpretation and reducing batch effects across multiple modalities.