Tze-Ling Chang

This study shows that YAP and TAZ redundantly regulate muscle regeneration by controlling proliferation and migration of muscle stem cells, revealing genetic redundancy as essential for regenerative robustness.

This study shows that aged fibroblasts impair muscle stem cell self-renewal by depositing excessive fibronectin in a 3D hydrogel co-culture system.

This study shows that the aged muscle tissue environment limits muscle stem cell function, and combined interventions can partially restore muscle mass in aged mice.

This study shows that activating FGFR1 restores Integrin-β1-mediated fibronectin sensing in aged satellite cells, improving their regenerative capacity.