Jesse V. Kurland

This study shows that the aged muscle tissue environment limits muscle stem cell function, and combined interventions can partially restore muscle mass in aged mice.

This study shows that activating FGFR1 restores Integrin-β1-mediated fibronectin sensing in aged satellite cells, improving their regenerative capacity.

The paper investigates NKX2-5 mutations in congenital heart disease by analyzing their epigenomic, biochemical, and chromatin search functions in cardiomyocytes, revealing diverse loss and gain-of-function defects.

The paper analyzes DNA binding effects of 92 human homeodomain mutants, identifying 14 novel specificity-determining residues and highlighting limitations of variant effect prediction tools.

The paper investigates myonuclear maturation dynamics in aged and adult regenerating mouse skeletal muscle, finding that transcriptional heterogeneity arises during maturation and is altered in aged muscle.

The paper identifies the DNA binding domain and sequence of SALL4, discovers its target genes in liver cancer cells, and reveals its mechanism of gene regulation.

The paper identifies three classes of enhancers regulated by Bicoid and Orthodenticle in Drosophila embryos, revealing a feed-forward relay mechanism that coordinates gene expression timing.