Lijin Zou

This paper demonstrates that chemically modified mRNA enhances bone marrow stem cell therapy to efficiently repair critical-sized cartilage defects in rats within 6 weeks.

The paper introduces TRAP-seq to quantify CRISPR editing efficiency and uses it to design improved gRNAs for Cas9, ABE, and CBE with high accuracy and efficiency.

This study explores the feasibility of using selective germline genome-edited pig meninges grafts for abdominal wall closure in damage control surgery, showing successful integration and revascularization in a rabbit model.

The paper creates a genetically modified pig with specific gene edits to enable immune tolerance in non-human primates and demonstrates long-term graft survival without immunosuppression.