Prashant Donthamsetti

The paper develops three far-red fluorescent antagonists as BRET tracers for D2R, enabling quantitative ligand binding measurements at recombinant and endogenous receptors.

The paper develops a photoswitchable antagonist for the dopamine D1 receptor to enable precise temporal and spatial control of receptor activity in the brain.

This paper demonstrates a chemical-optogenetic approach that restores high-sensitivity motion vision in an IRD mouse model using a multi-branched photoswitch.