René Holtackers

The paper uses live imaging and single-cell transcriptomics to study how extracellular matrix influences brain organoid development and regionalization.

The paper creates a multi-omic atlas of human neural organoids modeling the posterior brain and identifies morphogen conditions that expand organoid models.

The paper investigates chromatin dynamics in plant protoplasts during dedifferentiation, finding rapid multiscale changes influenced by nutrients and a decline in chromatin entropy over time.

scROSHI identifies cell types without training data by using pre-existing gene sets and hierarchical relationships, outperforming methods in low-data and high-diversity scenarios.

SCIM matches single-cell measurements across technologies by learning a technology-invariant latent space and applying bipartite matching, achieving high accuracy in real-world datasets.