Decoding morphogen patterning of human neural organoids with a multiplexed single-cell transcriptomic screen
Fátima Sanchís-Calleja, Nadezhda V. Azbukina, Akanksha Jain…·Barbara Treutlein
The paper uses a multiplexed single-cell transcriptomic screen to study how morphogen cues affect regional specification in human neural organoids, finding that timing, concentration, and combination of morphogens strongly influence cell type and regional composition.