Fátima Sanchís-Calleja

Luminal epithelium remodeling underlies endometrial regeneration during menstruation and pregnancy

This study shows that luminal epithelium, not glandular cells, drives endometrial regeneration during menstruation and pregnancy in mice, revealing a unifying mechanism for tissue repair.

Decoding morphogen patterning of human neural organoids with a multiplexed single-cell transcriptomic screen

The paper uses a multiplexed single-cell transcriptomic screen to study how morphogen cues affect regional specification in human neural organoids, finding that timing, concentration, and combination of morphogens strongly influence cell type and regional composition.

Morphodynamics of human early brain organoid development

The paper uses live imaging and single-cell transcriptomics to study how extracellular matrix influences brain organoid development and regionalization.

Mapping early patterning events in human neural development usingan in-vitro microfluidic stem cell model

The paper uses a microfluidic stem cell model to study early human neural patterning, identifying regional specification and fate determination during the epiblast stage.

CellFlow enables generative single-cell phenotype modeling with flow matching

CellFlow predicts single-cell phenotypes from complex perturbations using flow matching, demonstrating accuracy in cytokine stimulation, drug treatments, and developmental modeling.

Lineage recording reveals dynamics of cerebral organoid regionalization

The paper uses lineage recording techniques to study brain regionalization in cerebral organoids, finding that iPSC clones accumulate in distinct brain regions and lineage restriction increases over time.

Single-cell genomic atlas of great ape cerebral organoids uncovers human-specific features of brain development

This study uses single-cell genomics to compare brain development in humans, chimpanzees, and macaques, identifying human-specific gene regulatory features.