Nadezhda V. Azbukina

The paper introduces AIR-seq, a method that measures RNA dynamics without chemical conversion, improving RNA velocity inference and revealing hidden regulation.

The paper uses a multiplexed single-cell transcriptomic screen to study how morphogen cues affect regional specification in human neural organoids, finding that timing, concentration, and combination of morphogens strongly influence cell type and regional composition.

CellFlow predicts single-cell phenotypes from complex perturbations using flow matching, demonstrating accuracy in cytokine stimulation, drug treatments, and developmental modeling.

The paper creates a multi-omic atlas of human neural organoids modeling the posterior brain and identifies morphogen conditions that expand organoid models.