Author

Isabell Kassing

Charité – Universitätsmedizin BerlinORCID 0009-0006-8942-5348Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Research Focus:perturbation response prediction· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Ana-Maria NitulescuiD· 2 shared Dimitrios L. WagneriD· 2 shared Jonas KathiD· 2 shared Laura Marie HartmanniD· 2 shared Luis HuthiD· 2 shared Maik SteiniD· 2 shared Marie PouzollesiD· 2 shared Roberts KārkliņšiD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersSynthetic Biology

Ana-Maria NitulescuORCID

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2 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintSep 15, 2025

Repurposing base editors for targeted knock-in and simultaneous knockouts to generate multiplex-edited allogeneic CAR T cells with minimal translocations

Viktor Glaser, Lily Jo Becker, Carla Fuster‐García…·Dimitrios L. Wagner

This paper develops BEKI, a base editor-based method for targeted transgene insertion and multiplex gene disruption in T cells, reducing chromosomal translocations compared to Cas9-based approaches.

2 citations

humanCRISPR screen

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Synthetic BiologybioRxivPreprintSep 10, 2025

Versatile and efficient non-viral integration of large transgenes in human T cells via CRISPR knock-in and engineered integrases

Isabell Kassing, Jonas Kath, Ana-Maria Nitulescu…·Dimitrios L. Wagner

This paper introduces one-pot PASTA, a non-viral method for efficient large transgene integration in human T cells using CRISPR and integrases, showing improved performance over existing methods.

3 citations

humanCRISPR screen

𝕏 PostBluesky