Synthetic BiologybioRxivPreprint
Repurposing base editors for targeted knock-in and simultaneous knockouts to generate multiplex-edited allogeneic CAR T cells with minimal translocations
Viktor Glaser, Lily Jo Becker, Carla Fuster‐García…·Dimitrios L. Wagner
This paper develops BEKI, a base editor-based method for targeted transgene insertion and multiplex gene disruption in T cells, reducing chromosomal translocations compared to Cas9-based approaches.
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