Yvonne M. Heneka

This study identifies genomic features, particularly copy-number alterations, that predict metastatic progression in melanoma and defines a six-gene signature associated with relapse.

This study shows that CD44 deletion in pancreatic cancer-associated fibroblasts reduces tumor volume, alters their morphology and function, and enhances anti-tumor immune responses.

This study shows that targeting CD44v6/MET signaling disrupts colorectal cancer cell plasticity by repressing Lgr5+ cell reappearance and affecting YAP/TAZ signaling.