Jielei Wang

This paper develops a programmable platform to recruit RNA-binding proteins using small molecules, enabling RNA destabilization, and demonstrates its application to MAPT pre-mRNA.

SMARTPocket uses geometric deep learning to predict RNA-small molecule binding pockets from 3D structures, outperforming existing methods and identifying cryptic ligandable sites.

This study designs a covalent small molecule targeting unpaired guanines in a riboswitch, showing it modulates riboswitch function in a cellular reporter system.