Lingyin Li

This study shows that extracellular cGAMP worsens neuroinflammation in aging and MS by activating STING in microglia, astrocytes, and inhibitory neurons, with ENPP1 acting as a protective brake.

This study shows that the ENPP1 K173Q variant reduces cGAMP hydrolysis, leading to increased extracellular cGAMP and insulin resistance in brown adipose tissue.

The paper identifies SLC7A1 as the transporter for cGAMP and its analogs in T cells, showing that targeting this transporter can reduce toxicity without affecting arginine transport.

A small molecule blocks ENPP1, reviving immune attack on tumors and enhancing immune therapy with minimal side effects in preclinical cancer models.

This study identifies PTER as the taurine N-acetyltransferase/hydrolase, showing its role in regulating N-acetyltaurine levels and linking it to energy balance and metabolic phenotypes.

The paper identifies ENPP3 as a second cGAMP hydrolase, showing it regulates cGAMP levels and impacts cancer immunity.