Alessandra Sclip

Extracellular cGAMP transmission exacerbates neuroinflammation in aging and multiple sclerosis

This study shows that extracellular cGAMP worsens neuroinflammation in aging and MS by activating STING in microglia, astrocytes, and inhibitory neurons, with ENPP1 acting as a protective brake.

A combinatorial domain screening platform reveals epigenetic effector interactions for transcriptional perturbation

The paper introduces COMBINE, a platform that screens epigenetic effector domain pairs to identify synergistic and antagonistic interactions, revealing new mechanisms for transcriptional regulation.

Calsyntenin-3, an atypical cadherin, suppresses inhibitory basket- and stellate-cell synapses but boosts excitatory parallel-fiber synapses in cerebellum

This study shows that calsyntenin-3 deletion in Purkinje cells reduces inhibitory synapses while increasing excitatory parallel-fiber synapses, suggesting a novel role in regulating excitatory/inhibitory balance.

Compartment-Specific Neurexin Nanodomains Orchestrate Tripartite Synapse Assembly

This study shows that neurexin-1 in astrocytes and neurons forms distinct nanodomains at synapses, enabling compartment-specific signaling that differentially regulates synapse function.