Owen Richard Davies

This study uses C. elegans and mouse models to functionally validate infertility-associated genetic variants in MSH4, showing their pathogenic effects on meiotic processes in both sexes.

This study determines the molecular structure and function of HEI10, revealing its role in ubiquitin chain formation during meiosis.

This study identifies SYCP1 as a chromatin-bound regulator in breast cancer that promotes DNA repair, transcription, and drug resistance, with clinical implications for prognosis and therapy.

This paper introduces helical ensembles as improved search models for molecular replacement, achieving a 30% increase in solutions and faster convergence compared to ideal helices.

This paper introduces an ab-initio method to derive 3D protein structures from SAXS data and primary sequences, validated using crystal structures and showing success in modeling a coiled-coil protein.

The paper identifies 2747 SUMO modification sites in budding yeast meiosis, revealing SUMO's role in chromosome organization and recombination.

This study identifies distinct regions in the Zip1 protein that regulate crossover recombination and synapsis in budding yeast, showing their adjacency enables coordination between these processes.