Pharmacology & ToxicologybioRxivPreprint
Primary Human Macrophages Exhibit Functional CYP3A4 Activity with Marked Expression-Function Discordance and Cocaine-Induced Catalytic Activation
A C Price, Stephen A. Knerler, Rodnie Colón Ortiz…·Dionna W. Williams
This study shows human macrophages have functional CYP3A4 activity, with expression and function discordance, and cocaine increases CYP3A4 activity across donors.