Lei Chang

This study shows Lamin A/C regulates DNA replication by controlling chromatin accessibility and PCNA recruitment, preventing excessive replication initiation and DNA damage.

This study uses single-cell multi-omics to identify cell type-specific regulatory networks and novel therapeutic targets in MASLD.

The paper integrates single-cell multi-omics and 3D genome data from human hearts to identify gene regulatory changes and causal genetic contributors in heart failure.

This study identifies L1 and B1 retrotransposons as key elements shaping the 3D chromatin structure through spatial compartmentalization in human and mouse cells.

This study investigates the role of lamin B1 in chromatin architecture and dynamics using imaging and Hi-C sequencing, finding that lamin B1 depletion leads to chromatin decompaction and increased inter-chromosomal interactions.

This paper introduces a vector-independent method for multiplexed sgRNA expression, enabling efficient and scalable single non-repetitive DNA labeling and gene regulation in live cells.