Author

Steven J. Shaw

University of BristolORCID 0000-0002-1236-1810Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 3 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Assay:DNA methylation· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

Mark D. SzczelkuniD· 3 shared Aleksei AgapoviD· 1 shared Alex Hughes-GamesiD· 1 shared Anna OlinaiD· 1 shared Charlotte E. ChongiD· 1 shared D. Dunn· 1 shared David William AdamsiD· 1 shared Edze Rients WestraiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMicrobiology

Mark D. SzczelkunORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintSep 24, 2026

Dual ATPase-activated DNA hemimethylation and cleavage by the MANTIS defence system

Steven J. Shaw, Sam C Went, Aleksei Agapov…·Mark D. Szczelkun

The paper defines the mechanism of the MANTIS defence system in Pseudomonas aeruginosa, showing how dual ATPases couple self-modification to non-self restriction through adenine hemimethylation and cleavage.

DOI 10.64898/2026.09.23.753747

bacteria (other)DNA methylation

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MicrobiologybioRxivPreprintOct 16, 2025

Individual Staphylococcus aureus SauUSI restriction endonuclease motors fragment methylated DNA

S.J. Shaw, Alex Hughes-Games, Oscar Enrique Torres Montaguth…·Mark D. Szczelkun

This study investigates how the Staphylococcus aureus SauUSI restriction enzyme recognizes and cleaves methylated DNA through ATP-driven translocation and loop formation.

DOI 10.1101/2025.10.16.682607

bacteria (other)biophysical modeling

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MicrobiologyNature Structural & Molecular BiologyPeer-reviewedOct 14, 2025

Structure and Activation Mechanism of a Lamassu Phage Defence System

Yan Li, David William Adams, Hon Wing Liu…·Stephan Gruber

The paper presents structures of a Lamassu defence system from Salmonella enterica, revealing how LmuA nuclease effector is activated by oligomerization and DNA cleavage.

14 citationstop 2%

bacteria (other)structural biology

𝕏 PostBluesky