Author

L Y Li

Hospital for Sick ChildrenORCID 0009-0007-6468-9600Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Aideen Teeling· 1 shared Anjali Vig· 1 shared Antonio MollicaiD· 1 shared Benjamin Akman· 1 shared Christian Krustev· 1 shared Constance L. Smith‐HicksiD· 1 shared Dana J. PhilpottiD· 1 shared Emily ForsteriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Aideen Teeling

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2 papers

Recent·Most cited

Genetic & Genomic MedicineNature CommunicationsPeer-reviewedNov 27, 2025

Brain development mutations in the β-tubulin TUBB result in defective ciliogenesis

Antonio Mollica, Safia Omer, Georgiana Forguson…·Evgueni A. Ivakine

The paper identifies a novel TUBB mutation linked to both ciliopathy and tubulinopathy brain features, showing it impairs ciliogenesis by altering microtubule dynamics.

2 citations

humanwhole-genome sequencing

𝕏 PostBluesky

Cell BiologyCommunications BiologyPeer-reviewedMay 12, 2025

GSDMD pore formation regulates caspase-4 cleavage to limit IL-18 production in the intestinal epithelium

Jessica K. Bruce, L Y Li, Yu Tang…·Stephen E. Girardin

This study shows that GSDMD pore formation stops caspase-4 activity to control IL-18 production in intestinal epithelial cells, preventing excessive inflammation.

13 citations

humanmouse

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