Author

Jessica K. Bruce

University of TorontoORCID 0009-0008-6435-4269Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Dana J. PhilpottiD· 2 shared Nathaniel J. WinsoriD· 2 shared Simon KeelyiD· 2 shared Stephen E. GirardiniD· 2 shared Adrienne RangeriD· 1 shared Christian Krustev· 1 shared Emily C. HoedtiD· 1 shared Emily ForsteriD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

Dana J. PhilpottORCID

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3 papers

Recent·Most cited

MicrobiologyNeurogastroenterology & MotilityPeer-reviewedJan 1, 2026

Altered Duodenal Mucosa-Associated Microbiota and Immune Profiles in Functional Dyspepsia: A Study of Host-Microbiome Homeostasis

Emily C. Hoedt, Grace L. Burns, Seungha Kang…·Nicholas Joseph Talley

This study identifies distinct duodenal microbiota and immune profiles in functional dyspepsia patients compared to controls, suggesting disrupted host-microbiome homeostasis.

1 citation

humanbulk RNA-seq

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Cell BiologyCommunications BiologyPeer-reviewedMay 12, 2025

GSDMD pore formation regulates caspase-4 cleavage to limit IL-18 production in the intestinal epithelium

Jessica K. Bruce, L Y Li, Yu Tang…·Stephen E. Girardin

This study shows that GSDMD pore formation stops caspase-4 activity to control IL-18 production in intestinal epithelial cells, preventing excessive inflammation.

13 citations

humanmouse

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ImmunologybioRxivPreprintJul 18, 2024

NLRP1B allele 2 does not respond to Val-boro-Pro (VbP) in the intestinal epithelium

Ryan J. Mazzone, Nathaniel J. Winsor, Lu Yi Li…·Stephen E. Girardin

This study shows that NLRP1B allele 2 in intestinal epithelial cells does not respond to VbP, unlike in macrophages, suggesting allele-dependent regulation in IECs.

DOI 10.1101/2024.07.18.604161

mouseproteomics

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