Author

Isaiah O. Stephens

University of KentuckyORCID 0009-0007-7070-1805Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:metabolomics· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Lance A. JohnsoniD· 3 shared Diksha SatishiD· 2 shared Josh M. MorgantiiD· 2 shared Akhil V. PallerlaiD· 1 shared Cassi M. FridayiD· 1 shared Cathryn T SmithiD· 1 shared Chloe C. LucidoiD· 1 shared Danielle S. Goulding· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersNeuroscience

Lance A. JohnsonORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintJun 29, 2026

Anti-amyloid immunotherapy drives APOE4 specific increases in glial reactivity, perivascular immune activation, and ARIA-like events

Akhil V. Pallerla, Chloe C. Lucido, Kai Saito…·Lance A. Johnson

This study investigates how anti-amyloid immunotherapy affects APOE4 carriers, showing increased glial reactivity, perivascular immune activation, and ARIA-like events.

DOI 10.64898/2026.06.26.734793

mousespatial transcriptomics

𝕏 PostBluesky

NeuroscienceCellsPeer-reviewedNov 13, 2025

Knockout of Perilipin 2 in Microglia Alters Lipid Droplet Accumulation and Response to Alzheimer's Disease Stimuli

Isaiah O. Stephens, Lance A. Johnson

This study shows that knocking out Perilipin 2 in microglia reduces lipid droplet accumulation, enhances phagocytosis, and alters metabolic responses to Alzheimer's disease stimuli.

10 citations

mouseproteomics

𝕏 PostBluesky

PhysiologyNeurobiology of DiseasePeer-reviewedMay 30, 2025

APOE4 alters the lipid droplet proteome and modulates droplet dynamics

Cassi M. Friday, Isaiah O. Stephens, Cathryn T Smith…·Lance A. Johnson

This study shows that APOE4 increases lipid droplet accumulation and alters their composition in microglia, resembling a pro-inflammatory state, and overlaps with AD-associated proteomes.

37 citationstop 1%

mouseproteomics

𝕏 PostBluesky