Jade Desjardins

This study shows that combining dCas9 and Cas9 improves viability and reduces off-target effects when editing genes linked to viability or paralogous clusters.

This paper introduces a bioengineered stem cell organoid system to model human neural crest development, showing it recapitulates key developmental dynamics and can be used for cross-species validation.

This study investigates the functional effects of ALK variants in neural crest cells, showing that ALKF1174L increases migration and cytoskeletal protrusions through GSK3 binding.