Jack Toppen

The paper investigates Polycomb-mediated 3D chromatin interactions and finds that cPRC1 is not essential for their formation.

This study uses live-cell imaging to show that enhancer-promoter interactions drive gene activation through transient contacts of ~25-42 nanometers.

This paper proposes a new framework for development that emphasizes stochastic gene expression as a driving force rather than a noise, using reinforcement learning analogies to guide cell fates.

This paper introduces a computational pipeline using topological data analysis to quantify multicellular patterning in human induced pluripotent stem cell colonies, revealing subtle differences in differentiation stages.