Author

Miles K. Huseyin

University of OxfordORCID 0000-0002-0258-2994Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3 Genomics· 2 Biophysics· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 4 Assay:ChIP-seq· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:Hi-C· 1

Frequent Co-Authors

Neil P. BlackledgeiD· 4 shared Robert J. KloseiD· 4 shared Anders S. HanseniD· 3 shared Nadezda A. FursovaiD· 3 shared Angelika FeldmanniD· 2 shared Jack ToppeniD· 2 shared Paula Dobrinić· 2 shared Aleksander SzczurekiD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersMolecular Biology

Neil P. BlackledgeORCID

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Author profile →

7 papers

Recent·Most cited

Dissection of Polycomb complexes reveals canonical PRC1-independent 3D chromatin interactions

Miles K. Huseyin, Sumin Kim, Jack Toppen, Neil P. Blackledge, Anders S. Hansen

The paper investigates Polycomb-mediated 3D chromatin interactions and finds that cPRC1 is not essential for their formation.

bioRxiv · Oct 14, 2026 · PreprintGenomics

Live-cell imaging of enhancer-promoter dynamics reveals transient contact-driven gene activation

Jin Yang, Henrik Dahl Pinholt, Jack Toppen, Miles K. Huseyin, James M. Jusuf, Christos C. Katsifis, Jacob Kæstel‐Hansen, Leonid A. Mirny, Christoph Zechner, Anders S. Hansen

This study uses live-cell imaging to show that enhancer-promoter interactions drive gene activation through transient contacts of ~25-42 nanometers.

bioRxiv · Jun 21, 2026 · PreprintBiophysics

Region Capture Micro-C reveals coalescence of enhancers and promoters into nested microcompartments

Viraat Y. Goel, Miles K. Huseyin, Anders S. Hansen

The paper introduces RCMC, a method to capture deep 3D genome structure, revealing microcompartments where enhancers and promoters coalesce.

Nature Genetics · May 8, 2023Peer-reviewedGenomics

Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy

Miles K. Huseyin, Robert J. Klose

This study uses live-cell single particle tracking to show PRC1 has low chromatin occupancy and dynamic interactions, suggesting chromatin modification, not complex occupancy, drives gene repression.

Nature Communications · Feb 9, 2021Peer-reviewedMolecular Biology

BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome

Nadezda A. Fursova, Anne H. Turberfield, Neil P. Blackledge, Emma L. Findlater, Anna Lastuvkova, Miles K. Huseyin, Paula Dobrinić, Robert J. Klose

The paper shows that BAP1 limits H2AK119ub1 levels, which affects gene expression and Polycomb complex function, revealing a general mechanism for controlling transcriptional potential.

bioRxiv · Nov 13, 2020Molecular Biology

PRC1 catalytic activity is central to Polycomb system function.

Neil P. Blackledge, Nadezda A. Fursova, Jessica R. Kelley, Miles K. Huseyin, Angelika Feldmann, Robert J. Klose

This study investigates the role of PRC1 catalytic activity in Polycomb system function, showing it is essential for chromatin domain formation and gene repression.

Molecular Cell · Dec 26, 2019Peer-reviewedMolecular Biology

Cohesin disrupts polycomb-dependent chromosome interactions

JDP Rhodes, Angelika Feldmann, Benjamín Hernández-Rodríguez, Noèlia Díaz, JM Brown, Nadezda A. Fursova, Neil P. Blackledge, Praveen Prathapan, Paula Dobrinić, Miles K. Huseyin, Aleksander Szczurek, Kai Kruse, KA Nasmyth, VJ Buckle, Juan M. Vaquerizas, Robert J. Klose

The paper shows cohesin disrupts polycomb-dependent chromosomal interactions to regulate gene repression in embryonic stem cells.

bioRxiv · Mar 30, 2019 · PreprintGenetics