T. Boschert

This study identifies rare tumor-reactive T cells and conserved antigen repertoires in multiple myeloma and acute myeloid leukemia, developing a TCR fitness model to predict immunotherapy response.

makeTCR provides a modular platform for rapid, scalable, single-step TCR synthesis and validation, enabling functional testing within 48 hours.

T-FINDER identifies T cell epitopes and their cognate receptors by analyzing HLA-presented peptides, demonstrating its utility in multiple diseases.

This study describes a patient with diffuse midline glioma who achieved remission after vaccination with an H3K27M peptide vaccine, showing robust T and B cell responses across diverse HLA alleles.

ARDitox predicts TCR off-target binding using computational immunology and AI, identifying cross-reactive epitopes in cancer and viral targets.