Author

L. Bunse

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

M. PlatteniD· 3 shared C. L. TaniD· 2 shared E. W. GreeniD· 2 shared K. Lindner· 2 shared T. BoschertiD· 2 shared A. Blum· 1 shared A. Kaminitz· 1 shared A. Korshunov· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCancer Biology

M. PlattenORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Neoepitope-specific vaccination of a patient with diffuse midline glioma targeting H3K27M induces polyclonal B and T cell responses across diverse HLA alleles

T. Boschert, K. Kromer, T. Lerner, K. Lindner, G. Haltenhof, C. L. Tan, K. Jahne, I. Poschke, L. Bunse, N. Grassl, I. Mildenberger, K. Sahm, M. Platten, J. M. Lindner, E. W. Green

This study describes a patient with diffuse midline glioma who achieved remission after vaccination with an H3K27M peptide vaccine, showing robust T and B cell responses across diverse HLA alleles.

bioRxiv · Apr 28, 2023 · PreprintCancer Biology

ARDitox: platform for the prediction of TCRs potential off-target binding

V. Murcia Pienkowski, T. Boschert, P. Skoczylas, A. Sanecka-Duin, M. Jasinski, B. Krol-Jozaga, G. Mazzocco, S. Stachura, L. Bunse, J. Kaczmarczyk, E. W. Green, A. Blum

ARDitox predicts TCR off-target binding using computational immunology and AI, identifying cross-reactive epitopes in cancer and viral targets.

bioRxiv · Apr 11, 2023 · PreprintImmunology

MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors

M. Kilian, R. Sheinin, C. L. Tan, C. Kraemer, M. Friedrich, A. Kaminitz, K. Sanghvi, K. Lindner, F. Cichon, S. Jung, K. Jaehne, M. Ratliff, R. Prins, A. von Deimling, W. Wick, , M. Platten

This study shows that MHC class II antigen presentation on blood-borne myeloids is essential to maintain functional CD8+ T cells in brain tumors by preventing Tox-driven dysfunction.

Cancer Cell · Feb 1, 2023Peer-reviewedCancer Biology

A novel neural stem cell-derived immunocompetent mouse model of glioblastoma for preclinical studies

B. Costa, M. N. Fletcher, P. Boskovic, E. L. Ivanova, T. Eisemann, S. Lohr, L. Bunse, M. Loewer, S. Burchard, A. Korshunov, H.-K. Liu, M. Platten, B. Radlwimmer, P. Angel, H. Peterziel

This study develops a glioblastoma cell line from a genetic mouse model that mimics human glioblastoma features, enabling preclinical testing of immunotherapies.

bioRxiv · Mar 16, 2020 · PreprintCancer Biology