C. L. Tan

The paper identifies CD4+ tissue-resident memory T-cells as markers of response to immune checkpoint inhibition in high-grade glioma.

makeTCR provides a modular platform for rapid, scalable, single-step TCR synthesis and validation, enabling functional testing within 48 hours.

This study describes a patient with diffuse midline glioma who achieved remission after vaccination with an H3K27M peptide vaccine, showing robust T and B cell responses across diverse HLA alleles.

This study shows that MHC class II antigen presentation on blood-borne myeloids is essential to maintain functional CD8+ T cells in brain tumors by preventing Tox-driven dysfunction.