Hinrich Boeger

The paper uses long-read sequencing to study how nucleosome positioning affects isoform expression by analyzing chromatin and RNA in yeast.

The paper introduces SMAdd-seq, a method to profile chromatin accessibility using small molecule intercalation and nanopore sequencing, and demonstrates its application in yeast.

The paper shows that transcriptional regulation in yeast is cyclic and irreversible, violating thermodynamic equilibrium.

This study determines the structure of the MuvB complex and shows it binds and stabilizes nucleosomes downstream of the transcription start site to repress gene expression.

The paper analyzes regulatory elements in yeast to understand their interactions and develops methods to estimate their contributions to gene expression.