Author

Ashley B. Niesman

The University of Texas Southwestern Medical CenterORCID 0009-0008-0118-7483Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 2 Approach:microscopy & imaging analysis· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

Yuh Min ChookiD· 4 shared Binita Shakya· 2 shared Ho Yee Joyce FungiD· 2 shared Abby WalterscheidiD· 1 shared Ahmet E. Cansizoglu· 1 shared Bert KwanteniD· 1 shared Brecht PermentieriD· 1 shared Casey E. WingiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersBiochemistry

Yuh Min ChookORCID

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4 papers

Recent·Most cited

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedMay 1, 2026

Importins recognize the winged-helix fold of ETS transcription factors to mediate nuclear import

Michael McConville, Kaylee P. Lankford, Natália Elisa Bernardes…·Glen Liszczak

The paper identifies the ETS domain as a structure-encoded NLS recognized by importins, revealing how importins mediate nuclear import of ETS transcription factors.

DOI 10.1073/pnas.2536763123

humanstructural biology

𝕏 PostBluesky

Cancer BiologyNature Chemical BiologyPeer-reviewedNov 21, 2025

SINE compounds activate exportin-1 degradation via an allosteric mechanism

Casey E. Wing, Ho Yee Joyce Fung, Bert Kwanten…·Yuh Min Chook

This paper reveals that SINE compounds induce XPO1 degradation via an allosteric mechanism involving ASB8, distinct from molecular glue degraders.

12 citations

humanprotein structure

𝕏 PostBluesky

BiochemistryJournal of Biological ChemistryPeer-reviewedMay 6, 2025

Setdb1 and Atf7IP form a hetero-trimeric complex that blocks Setdb1 nuclear export

Leena S. Kariapper, Ila A. Marathe, Ashley B. Niesman…·Evan J. Worden

This study identifies a hetero-trimeric complex formed by Setdb1 and two Atf7IP copies that blocks Setdb1 nuclear export by competing with CRM1.

1 citation

biophysical modelingchromatin & epigenetic regulation

𝕏 PostBluesky

BiophysicsNature CommunicationsPeer-reviewedMar 15, 2025

Phosphate-dependent nuclear export via a novel NES class recognized by exportin Msn5

Ho Yee Joyce Fung, Sanraj R. Mittal, Ashley B. Niesman…·Yuh Min Chook

The paper identifies a novel phosphorylated NES in Pho4 recognized by Msn5, revealing a phosphate-specific nuclear export mechanism in yeast.

6 citations

yeastcryo-EM

𝕏 PostBluesky