Ho Yee Joyce Fung

SINE compounds activate exportin-1 degradation via an allosteric mechanism

This paper reveals that SINE compounds induce XPO1 degradation via an allosteric mechanism involving ASB8, distinct from molecular glue degraders.

A genome-scale drug discovery pipeline uncovers new therapeutic targets and a unique p97 allosteric binding site in Schistosoma mansoni

This paper identifies new drug targets in Schistosoma mansoni using a genome-scale pipeline and discovers a p97 allosteric binding site that could lead to species-selective inhibitors.

Phosphate-dependent nuclear export via a novel NES class recognized by exportin Msn5

The paper identifies a novel phosphorylated NES in Pho4 recognized by Msn5, revealing a phosphate-specific nuclear export mechanism in yeast.

Structural basis for Retriever-SNX17 assembly and endosomal sorting

This study determines the structure of the Retriever-SNX17 complex using cryo-EM, revealing how SNX17 interacts with Retriever to facilitate endosomal sorting of cargo proteins.

Structure of Importin-4 bound to the H3-H4·ASF1 histone·histone chaperone complex

This study determines the structure of Importin-4 bound to the H3-H4·ASF1 complex, revealing how Importin-4 recognizes and transports the histone chaperone complex into the nucleus.