SINE compounds activate exportin-1 degradation via an allosteric mechanism
Casey E. Wing, Ho Yee Joyce Fung, Bert Kwanten, Tolga Çağatay, Ashley B. Niesman, Maarten Jacquemyn, Mehdi Gharghabi, Brecht Permentier, Binita Shakya, Rhituparna Nandi, Joseph M. Ready, Trinayan Kashyap, Sharon Shacham, Yosef Landesman, Rosa Lapalombella, , Yuh Min Chook
This paper reveals that SINE compounds induce XPO1 degradation via an allosteric mechanism involving ASB8, distinct from molecular glue degraders.
Nature Chemical Biology · Nov 21, 2025Peer-reviewedCancer Biology