Michaela Y. Guo

The paper identifies Tshz1 neurons in the nucleus accumbens as critical for withdrawal aversion by modulating dopamine release and mGluR8 activity, offering a new therapeutic target for opioid use disorder.

The paper shows dopamine and serotonin regulate striatal output pathways through distinct neuronal populations, achieving opponent effects.

This study shows that integrating inverse dopamine and serotonin signals in the striatum is essential for associative learning.