Local control of dopamine release in nucleus accumbens gates opioid withdrawal aversion
Matthew B. Pomrenze, Jason Tucciarone, Gavin C. Touponse, Nicholas Denomme, BaDoi N. Phan, Robyn St. Laurent, Julia A Galiza Soares, Daniel F. Cardozo Pinto, Michaela Y. Guo, Jinhee Baek, Allen P. F. Chen, Zihui Zhang, Amei N. Shank, Zachary Freyberg, Andreas R. Pfenning, , Robert C. Malenka
The paper identifies Tshz1 neurons in the nucleus accumbens as critical for withdrawal aversion by modulating dopamine release and mGluR8 activity, offering a new therapeutic target for opioid use disorder.
bioRxiv · May 28, 2026 · PreprintNeuroscience