Sadia Siddika Dima

The paper introduces EAGER, a model that incorporates enhancer activity to predict gap gene expression across the entire Drosophila AP axis, and validates it using Kr mutants.

The paper quantifies Bicoid/DNA interactions in Drosophila to model transcriptional regulation and explains the sharp posterior boundary of hunchback gene expression.

The paper quantifies Dorsal concentration, binding, and mobility in Drosophila embryos, revealing threshold-based formation of DNA-bound and mobile clusters linked to gene regulation.

The paper quantifies Dorsal/NF-κB mobility and DNA binding along the dorsal-ventral axis of Drosophila embryos, revealing a gradient in DNA binding that affects gradient formation and downstream gene expression.

The paper maps the dose/response relationships between bulk TF concentrations and DNA binding during Drosophila ZGA, revealing distinct dynamics for Zelda and GAGA factor.

This study visualizes Cactus dynamics in Drosophila embryos using LlamaTag and optical techniques, revealing nuclear localization and biophysical parameters of the NF-κB pathway.

The paper introduces four new fluorescent protein fusions for Dorsal to study its dynamics in fruit fly embryos.