Gregory T. Reeves

The paper introduces EAGER, a model that incorporates enhancer activity to predict gap gene expression across the entire Drosophila AP axis, and validates it using Kr mutants.

The paper quantifies Bicoid/DNA interactions in Drosophila to model transcriptional regulation and explains the sharp posterior boundary of hunchback gene expression.

The paper quantifies Dorsal concentration, binding, and mobility in Drosophila embryos, revealing threshold-based formation of DNA-bound and mobile clusters linked to gene regulation.

The paper quantifies Dorsal/NF-κB mobility and DNA binding along the dorsal-ventral axis of Drosophila embryos, revealing a gradient in DNA binding that affects gradient formation and downstream gene expression.

The paper introduces MIDOE, a method to design experiments that optimally constrain model predictions of Smad2-Smad4 dynamics, improving predictive power and reducing experimental costs.

The paper maps the dose/response relationships between bulk TF concentrations and DNA binding during Drosophila ZGA, revealing distinct dynamics for Zelda and GAGA factor.

This study visualizes Cactus dynamics in Drosophila embryos using LlamaTag and optical techniques, revealing nuclear localization and biophysical parameters of the NF-κB pathway.

CalciumInsights provides a user-friendly tool for analyzing calcium signals across multiple organisms and tissues without requiring programming expertise.

The paper introduces four new fluorescent protein fusions for Dorsal to study its dynamics in fruit fly embryos.

The paper develops a mathematical model to study how Dad and Fused regulate stem cell division in Drosophila, showing their synergistic role in maintaining GSC homeostasis and differentiation.

The paper examines how the BMP-Smad pathway balances trade-offs among response speed, noise amplification, and sensitivity to receptor input by tuning non-conserved parameters.

ISRES+ improves parameter estimation in systems biology models by enhancing an evolutionary strategy to better minimize error functions.

The paper examines the dynamics of BMP signaling in Drosophila embryos and finds that target gene activation persists even after the signal is lost, suggesting a memory mechanism.

The paper investigates how the Dorsal morphogen gradient remains robust to variations in maternal dorsal mRNA dosage, identifying three mechanisms that contribute to this robustness.

The paper studies the spatiotemporal behavior of a feedforward loop in morphogen gradients and finds structure-dependent dynamics in gene expression boundaries.

The paper demonstrates that the Dorsal/NF-κB morphogen gradient in Drosophila embryos is established via shuttling by Cactus/IκB, enabling viability of embryos with one maternal copy of dorsal.

The paper identifies novel regulatory factors affecting anterior-posterior patterning in Drosophila by analyzing natural genetic variation in gene expression boundaries.