Doris Kaltenecker

Deep Learning and 3D Imaging Reveal Whole-Body Alterations in Obesity

This paper introduces MouseMapper, a deep learning tool combined with 3D imaging to analyze whole-body structural changes in obesity, revealing nerve and immune system alterations.

Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution compared to standard antibodies

This study compares the biodistribution of Fc-engineered molecules targeting BBB receptors with standard antibodies, showing distinct CNS and peripheral organ targeting.

Virtual reality empowered deep learning analysis of brain activity

DELiVR uses VR-generated data to train deep learning models for quantifying c-Fos in cleared mouse brains, revealing new activation patterns in cancer-related brain activity.