Cyrus Y. Jin

The paper shows that structural ubiquitin contributes to K48 linkage-specificity in Tom1 through a non-canonical binding site identified via cryo-EM.

This study identifies HAPSTR1 as a HUWE1 substrate that facilitates its nuclear localization, thereby regulating stress signaling pathways and cell proliferation.

The paper presents cryo-EM structures of BIRC6-client complexes to elucidate the mechanism of Smac-mediated caspase release and BIRC6 function in apoptosis regulation.

The paper presents the cryo-EM structure of HUWE1, revealing its modular architecture and its role in degrading cell-fate decision factors.