Daan Overwijn

This study identifies PAIP1 as a cofactor for mRNA export and shows it couples nuclear to cytoplasmic mRNP remodeling and poly(A) homeostasis, affecting mRNA stability and development.

This study examines how protein tags affect condensate formation in different contexts and identifies charge as a key factor influencing condensation behavior.

The paper shows that structural ubiquitin contributes to K48 linkage-specificity in Tom1 through a non-canonical binding site identified via cryo-EM.

This study identifies LRBA's role in regulating the endosomal-lysosomal pathway by controlling Rab4+ endosome traffic, leading to enlarged endolysosomes in LRBA-deficient patients.

The paper presents the cryo-EM structure of HUWE1, revealing its modular architecture and its role in degrading cell-fate decision factors.