Author

Jeffrey J. Babon

The University of MelbourneORCID 0000-0002-5408-6239Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Approach:biophysical modeling· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1

Frequent Co-Authors

Alexandra L. GarnhamiD· 1 shared Andrew J. KuehiD· 1 shared Andrew P. LeisiD· 1 shared Anna Gabrielyan· 1 shared Anthony CerraiD· 1 shared Bailey E. WilliamsiD· 1 shared Benjamin J. BroomfieldiD· 1 shared Brigette C. DuckworthiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperCell Biology

Alexandra L. GarnhamORCID

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3 papers

Recent·Most cited

ZnF-UBP domains regulate deubiquitinase activity by relieving ubiquitin product inhibition

Jack A Alexandrovics, Rashmi Agrata, Jan André Hane, Philipp Schenk, Anthony Cerra, Ueli Nachbur, Malte Gersch, Jeffrey J. Babon, David Komander

The paper investigates ZnF-UBP domains in USP DUBs, showing they relieve product inhibition by facilitating Ub release, thereby regulating enzyme activity.

Nature Communications · Jul 17, 2026Peer-reviewedBiochemistry

Cryo-EM structure of human LRRC15 reveals the basis of therapeutic antibody recognition

Xiaomin Wang, Mihin Perera, Maryam Sana, Chunxiao Wang, Ching‐Seng Ang, Hariprasad Venugopal, Phillip Pymm, Wai‐Hong Tham, Jeffrey J. Babon, Andrew P. Leis, Rhys Grinter, Shabih Shakeel

The paper determines the cryo-EM structure of LRRC15 and identifies the epitope recognized by the antibody samrotamab, revealing a binding mode that preserves signaling surfaces.

bioRxiv · Jun 18, 2026 · PreprintBiochemistry

ARAP2 regulates responses to interferon-gamma by restricting SOCS1

Narelle Keating, Karen Doggett, Grace M. Bidgood, Lizeth G. Meza Guzman, Laura F. Dagley, Kunlun Li, Bailey E. Williams, Anna Gabrielyan, Carolina Alvarado, Benjamin J. Broomfield, Brigette C. Duckworth, Colin Hockings, Jumana M. Yousef, Evelyn Leong, Rhiannon Morris, , Sandra E. Nicholson

This study identifies ARAP2 as a regulator of IFN-gamma signaling by modulating SOCS1 function through a phosphorylation-dependent interaction.

Cell Reports · Dec 1, 2025Peer-reviewedCell Biology